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Image Search Results
Journal: Nature Communications
Article Title: A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development
doi: 10.1038/s41467-023-44506-2
Figure Lengend Snippet: a Newborn 3D CT with reconstruction demonstrating partial calvaria. b Newborn brain MRI demonstrating hypoplastic cerebellum and brainstem. c UCSC Genome Browser shot showing duplicated region identified in this patient. d Differentially expressed genes across multiple replicates ( n = 3) and clones ( n = 5) of patient neural crest cells compared to neural crest derived from control cell lines ( n = 4) (CTRL). e Network plot of enriched gene ontology terms of all significantly dysregulated genes between WT and patient neural crest. f Normalized counts from all patient-derived NCC RNA-Seq. g Transcription factor co-occurrence scores reported by Enrichr for upregulated (red), downregulated (green), and non-differentially expressed genes (blue) for each of the HOXA TFs. h Significant disease ontology categories identified by Fisher Exact Test (one-sided, Benjamini-Hochberg adjusted) calculated by DisGeNet for down and upregulated genes in patient neural crest.
Article Snippet:
Techniques: Clone Assay, Derivative Assay, Control, RNA Sequencing